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Cell-Penetrating · Cell-penetrating peptide (CPP) · TAT-004

Ala-Leu-Ala-Leu

Research use · ships internationally
$95.00 / 1mg vial
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Ala-Leu-Ala-Leu reference vial
Drug class
Cell-penetrating peptide (CPP)
Status
Research use only
Catalog code
TAT-004
Also known as
TAT-004
Reviewed
2026-06-01 · Kindr Health Clinical Team

What Ala-Leu-Ala-Leu is studied for

  • Intracellular cargo delivery (peptides, siRNA, proteins)
  • Endosomal-escape and trafficking studies
  • In vitro screens of CPP variants for uptake efficiency
  • Structure–activity work on cationic / amphipathic CPPs

Mechanism of action

Ala-Leu-Ala-Leu sits within the Cell-Penetrating research class (CPC reference TAT-004). CPPs cross cellular membranes through energy-independent direct translocation and/or endocytic uptake driven by cationic residues (arginine-rich sequences) or amphipathic architecture. They are typically conjugated to a cargo of interest. Investigators typically incorporate Ala-Leu-Ala-Leu as a reference standard, tool ligand, or substrate in the assay contexts listed above. Fluorescent-conjugate flow cytometry and confocal imaging are the standard uptake readouts.

Frequently asked questions

What is Ala-Leu-Ala-Leu?

Ala-Leu-Ala-Leu (CPC catalog code TAT-004) is a synthetic cell-penetrating peptide (cpp) in the cell-penetrating category. It is provided as a lyophilized ~1 mg vial for in-vitro research use only.

What is Ala-Leu-Ala-Leu studied for?

Published and internal research programs use Ala-Leu-Ala-Leu as a reference standard in cell-penetrating workflows — for example, intracellular cargo delivery (peptides, sirna, proteins) and endosomal-escape and trafficking studies. Human clinical evidence is not established.

Is Ala-Leu-Ala-Leu FDA-approved for human use?

No. Ala-Leu-Ala-Leu is a research-grade reference peptide and is not approved by the FDA or any national regulator for human or veterinary therapeutic use. It is offered exclusively for in-vitro laboratory research and does not ship to the United States for consumer use.

How is Ala-Leu-Ala-Leu typically used in the lab?

In a cell-penetrating workflow, Ala-Leu-Ala-Leu is reconstituted in sterile buffer or DMSO (solubility-dependent) and applied in the researcher's chosen assay format. Fluorescent-conjugate flow cytometry and confocal imaging are the standard uptake readouts.

How should Ala-Leu-Ala-Leu be stored?

Store lyophilized at −20 °C. Aliquot reconstituted stocks to avoid freeze–thaw damage. Follow your institution's standard operating procedures for handling synthetic peptides.

Where does the Ala-Leu-Ala-Leu product page point to?

This kindr reference page mirrors CPC Scientific's catalog metadata for TAT-004. The upstream reference sheet — including sequence, purity, MW, and application notes where published — is linked from the buy panel. All orders placed on kindr Peptides ship internationally under research-use terms only.

What quality specifications apply to Ala-Leu-Ala-Leu?

Research-grade peptides in the CPC catalog are synthesized by solid-phase peptide synthesis (SPPS), purified by preparative RP-HPLC, and characterized by analytical HPLC and mass spectrometry. Typical purity is ≥95%; certificate of analysis is available on request.

Internal reference sheetOpen the Ala-Leu-Ala-Leu physicochemical & handling reference →Upstream reference sheetView CPC Scientific catalog page for TAT-004 →Add to cart · International research catalogBuy Ala-Leu-Ala-Leu in the kindr Peptides Shop →

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Research & medical disclosure. This page is educational reference content reviewed by a licensed physician. It is not medical advice and does not establish a clinician–patient relationship. Peptides offered on the kindr Peptides Shop are sold for in vitro laboratory research purposes only and ship worldwide, including the United States. For U.S. clinical care, use the kindr Longevity intake.