We use cookies to analyze site usage and improve your experience. You can accept all, reject non-essential, or customize. See our Privacy Policy.
Reference sheet · Cell-Penetrating · CPC catalog code TAT-003
Composition figures above are derived arithmetically from the published sequence for the unmodified free peptide. Salt forms (commonly trifluoroacetate or acetate), amidation, and other modifications shift the observed mass — always reconcile against the current lot certificate of analysis.
Volumes for a 1 mg vial of TAT 2-4 at common working concentrations. Add solvent slowly down the vial wall and swirl — do not vortex or shake.
Reference standards in the Cell-Penetrating class are typically shipped as lyophilized powder and stored desiccated at −20 °C protected from light. Once reconstituted in bacteriostatic water or the assay-appropriate buffer, aliquot and store at −80 °C to minimize freeze–thaw cycles. Confirm handling requirements against your institutional biosafety and radiation protocols before use.
TAT 2-4 sits within the Cell-Penetrating research class (CPC reference TAT-003). CPPs cross cellular membranes through energy-independent direct translocation and/or endocytic uptake driven by cationic residues (arginine-rich sequences) or amphipathic architecture. They are typically conjugated to a cargo of interest. Investigators typically incorporate TAT 2-4 as a reference standard, tool ligand, or substrate in the assay contexts listed above. Fluorescent-conjugate flow cytometry and confocal imaging are the standard uptake readouts.
TAT 2-4 (CPC catalog code TAT-003) is a synthetic cell-penetrating peptide (cpp) in the cell-penetrating category. It is provided as a lyophilized ~1 mg vial for in-vitro research use only.
Published and internal research programs use TAT 2-4 as a reference standard in cell-penetrating workflows — for example, intracellular cargo delivery (peptides, sirna, proteins) and endosomal-escape and trafficking studies. Human clinical evidence is not established.
No. TAT 2-4 is a research-grade reference peptide and is not approved by the FDA or any national regulator for human or veterinary therapeutic use. It is offered exclusively for in-vitro laboratory research and does not ship to the United States for consumer use.
In a cell-penetrating workflow, TAT 2-4 is reconstituted in sterile buffer or DMSO (solubility-dependent) and applied in the researcher's chosen assay format. Fluorescent-conjugate flow cytometry and confocal imaging are the standard uptake readouts.
Other reference standards in the same class — commonly cross-referenced during assay design and comparator selection.