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Opioid · Opioid-receptor research peptide · ENDP-008

a-Endorphin

Research use · ships internationally
$85.00 / 1mg vial
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a-Endorphin reference vial
Drug class
Opioid-receptor research peptide
Status
Research use only
Catalog code
ENDP-008
Also known as
ENDP-008
Reviewed
2026-06-01 · Kindr Health Clinical Team

What a-Endorphin is studied for

  • Opioid-receptor binding and selectivity profiling
  • β-arrestin recruitment and biased-agonism studies
  • Analgesic mechanism research
  • Tolerance and dependence models

Mechanism of action

a-Endorphin sits within the Opioid research class (CPC reference ENDP-008). Opioid peptides bind μ, δ, and κ receptors — Gi/o-coupled GPCRs that inhibit adenylate cyclase, activate GIRK channels, and modulate calcium currents to produce analgesia, tolerance, and reward-circuit effects. Investigators typically incorporate a-Endorphin as a reference standard, tool ligand, or substrate in the assay contexts listed above. GTPγS binding, cAMP HTRF, and β-arrestin PathHunter assays.

Frequently asked questions

What is a-Endorphin?

a-Endorphin (CPC catalog code ENDP-008) is a synthetic opioid-receptor research peptide in the opioid category. It is provided as a lyophilized ~1 mg vial for in-vitro research use only.

What is a-Endorphin studied for?

Published and internal research programs use a-Endorphin as a reference standard in opioid workflows — for example, opioid-receptor binding and selectivity profiling and β-arrestin recruitment and biased-agonism studies. Human clinical evidence is not established.

Is a-Endorphin FDA-approved for human use?

No. a-Endorphin is a research-grade reference peptide and is not approved by the FDA or any national regulator for human or veterinary therapeutic use. It is offered exclusively for in-vitro laboratory research and does not ship to the United States for consumer use.

How is a-Endorphin typically used in the lab?

In a opioid workflow, a-Endorphin is reconstituted in sterile buffer or DMSO (solubility-dependent) and applied in the researcher's chosen assay format. GTPγS binding, cAMP HTRF, and β-arrestin PathHunter assays.

How should a-Endorphin be stored?

Store lyophilized at −20 °C. Handle as Schedule research reagents where applicable. Follow your institution's standard operating procedures for handling synthetic peptides.

Where does the a-Endorphin product page point to?

This kindr reference page mirrors CPC Scientific's catalog metadata for ENDP-008. The upstream reference sheet — including sequence, purity, MW, and application notes where published — is linked from the buy panel. All orders placed on kindr Peptides ship internationally under research-use terms only.

What quality specifications apply to a-Endorphin?

Research-grade peptides in the CPC catalog are synthesized by solid-phase peptide synthesis (SPPS), purified by preparative RP-HPLC, and characterized by analytical HPLC and mass spectrometry. Typical purity is ≥95%; certificate of analysis is available on request.

Internal reference sheetOpen the a-Endorphin physicochemical & handling reference →Upstream reference sheetView CPC Scientific catalog page for ENDP-008 →Add to cart · International research catalogBuy a-Endorphin in the kindr Peptides Shop →

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Research & medical disclosure. This page is educational reference content reviewed by a licensed physician. It is not medical advice and does not establish a clinician–patient relationship. Peptides offered on the kindr Peptides Shop are sold for in vitro laboratory research purposes only and ship worldwide, including the United States. For U.S. clinical care, use the kindr Longevity intake.