We value your privacy

We use cookies to analyze site usage and improve your experience. You can accept all, reject non-essential, or customize. See our Privacy Policy.

Peptides shop · (Val671)-Amyloid b/A4 Protein Precursor770 (667-676) · Reference sheet

(Val671)-Amyloid b/A4 Protein Precursor770 (667-676)

Reference sheet · Neurodegenerative · CPC catalog code AMYD-115

Identity

Name
(Val671)-Amyloid b/A4 Protein Precursor770 (667-676)
Catalog code
AMYD-115
Category
Neurodegenerative

Physicochemical properties

Sequence
H-Ser-Glu-Val-Lys-Val-Asp-Ala-Glu-Phe-Arg-OH (trifluoroacetate salt)
One-letter
SEVKVDAEFR
Residues
10 amino acids
Molecular formula
C51H82N14O18 computed from sequence
Molecular weight
1179.3 g/mol average mass, free peptide, computed
Net charge (pH 7)
-1 (2 basic / 3 acidic)
Hydrophobic residues
40%
Cysteine present
No

Composition figures above are derived arithmetically from the published sequence for the unmodified free peptide. Salt forms (commonly trifluoroacetate or acetate), amidation, and other modifications shift the observed mass — always reconcile against the current lot certificate of analysis.

Reconstitution reference

Volumes for a 1 mg vial of (Val671)-Amyloid b/A4 Protein Precursor770 (667-676) at common working concentrations. Add solvent slowly down the vial wall and swirl — do not vortex or shake.

10 mg/mL
0.1 mL diluent per 1 mg
5 mg/mL
0.2 mL diluent per 1 mg
2 mg/mL
0.5 mL diluent per 1 mg
1 mg/mL
1 mL diluent per 1 mg

Handling, storage & reconstitution

Upstream storage
-20 ± 5 °C

General guidance for this class

Reference standards in the Neurodegenerative class are typically shipped as lyophilized powder and stored desiccated at −20 °C protected from light. Once reconstituted in bacteriostatic water or the assay-appropriate buffer, aliquot and store at −80 °C to minimize freeze–thaw cycles. Confirm handling requirements against your institutional biosafety and radiation protocols before use.

Mechanism & research applications

(Val671)-Amyloid b/A4 Protein Precursor770 (667-676) sits within the Neurodegenerative research class (CPC reference AMYD-115). These peptides (amyloid-β, α-synuclein, tau, prion fragments) form ordered β-sheet aggregates and oligomeric species that are used to interrogate seeding, propagation, and cellular toxicity mechanisms of neurodegeneration. Investigators typically incorporate (Val671)-Amyloid b/A4 Protein Precursor770 (667-676) as a reference standard, tool ligand, or substrate in the assay contexts listed above. ThT fluorescence, AFM / TEM morphology, and neuronal-toxicity readouts (LDH, MTT).

Studied for

  • Aggregation kinetics (ThT, ANS fluorescence) studies
  • Oligomer- and fibril-mediated toxicity assays
  • Seeding and prion-like propagation models
  • Aggregation-inhibitor and antibody screening

Frequently asked

What is (Val671)-Amyloid b/A4 Protein Precursor770 (667-676)?

(Val671)-Amyloid b/A4 Protein Precursor770 (667-676) (CPC catalog code AMYD-115) is a synthetic neurodegenerative-disease research peptide in the neurodegenerative category. It is provided as a lyophilized ~1 mg vial for in-vitro research use only.

What is (Val671)-Amyloid b/A4 Protein Precursor770 (667-676) studied for?

Published and internal research programs use (Val671)-Amyloid b/A4 Protein Precursor770 (667-676) as a reference standard in neurodegenerative workflows — for example, aggregation kinetics (tht, ans fluorescence) studies and oligomer- and fibril-mediated toxicity assays. Human clinical evidence is not established.

Is (Val671)-Amyloid b/A4 Protein Precursor770 (667-676) FDA-approved for human use?

No. (Val671)-Amyloid b/A4 Protein Precursor770 (667-676) is a research-grade reference peptide and is not approved by the FDA or any national regulator for human or veterinary therapeutic use. It is offered exclusively for in-vitro laboratory research and does not ship to the United States for consumer use.

How is (Val671)-Amyloid b/A4 Protein Precursor770 (667-676) typically used in the lab?

In a neurodegenerative workflow, (Val671)-Amyloid b/A4 Protein Precursor770 (667-676) is reconstituted in sterile buffer or DMSO (solubility-dependent) and applied in the researcher's chosen assay format. ThT fluorescence, AFM / TEM morphology, and neuronal-toxicity readouts (LDH, MTT).

Sources

View full product page →Back to catalog

Related peptides in Neurodegenerative

Other reference standards in the same class — commonly cross-referenced during assay design and comparator selection.

(Asn670,Leu671)-Amyloid b/A4 Protein Precursor770 (667-676)
(Asn670,Leu671)-Amyloid b/A4 Protein Precursor770 (667-675)
MCA-Amyloid b/A4 Protein Precursor770 (667-676)-Lys(DNP)-Arg-Arg Amide
Amyloid beta/A4 Protein Precursor770 (135-155)
Amyloid beta/A4 Protein Precursor770 (740-770)
DABCYL-(Asn670,Leu671)-Amyloid b/A4 Protein Precursor770 (667-675)-EDANS
Mca-(Asn670,Leu671)-Amyloid b/A4 Protein Precursor770 (667-674)-Dap(DNP)
MCA-(Asn670,Leu671)-Amyloid b/A4 Protein Precursor770 (667-675)-Lys(DNP)
Research use only. The peptides referenced on this page are supplied to qualified laboratories for in-vitro or non-human research. They are not drugs, foods, cosmetics, or dietary supplements, are not for human consumption, and are not intended to diagnose, treat, cure, or prevent any disease. Physicochemical values shown here are transcribed from the cited upstream reference sheet(s); confirm with your own certificate of analysis before use.