HRT · Post-surgical
HRT after hysterectomy: estrogen-only guide
If your uterus has been removed, endometrial protection is unnecessary in most cases. Estrogen-only therapy — the arm of the WHI that actually reduced breast cancer incidence — is the standard approach.
Estrogen-only regimens
- Estradiol patch 0.025–0.1mg/day
- Estradiol gel/spray
- Oral estradiol 1–2mg if no clot risk
Frequently asked questions
Do I need progesterone after hysterectomy?
Usually no. Exceptions: prior endometriosis or ovarian remnant syndrome.
What did WHI show for estrogen-only?
In the CEE-alone arm (hysterectomy cohort), breast cancer incidence was lower than placebo.
How long can I stay on it?
No arbitrary stop date. Duration is a shared decision based on ongoing benefit.
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Written and medically reviewed by the Kindr Health Clinical Team · Published 2026-06-19 · Last reviewed 2026-07-01. Compounded medications are prepared by FDA-registered 503A pharmacies and are not FDA-approved drug products.