Weight Loss

Authoritative sources

• Wikidata (Q504674)
• MeSH (D015431)
• Wikipedia

Evidence base

• Randomized Controlled Trial · 2022 · Landmark

  Tirzepatide Once Weekly for the Treatment of Obesity

  New England Journal of Medicine · Jastreboff AM, Aronne LJ, Ahmad NN, et al. (SURMOUNT-1)

  The pivotal trial that established tirzepatide (Zepbound / Mounjaro) as the most effective medication studied for weight loss to date.

• Randomized Controlled Trial · 2021 · Landmark

  Once-Weekly Semaglutide in Adults with Overweight or Obesity

  New England Journal of Medicine · Wilding JPH, Batterham RL, Calanna S, et al. (STEP 1)

  The pivotal trial that established semaglutide (Wegovy) as a highly effective medication for weight loss in adults without diabetes.

• Randomized Controlled Trial · 2025

  Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity

  The New England journal of medicine · Packer M, Zile MR, Kramer CM, Baum SJ, et al.

• Randomized Controlled Trial · 2025

  Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity

  The New England journal of medicine · Garvey WT, Blüher M, Osorto Contreras CK, Davies MJ, et al.

• Meta-Analysis · 2024

  Long-Term Efficacy and Safety of Once-Weekly Semaglutide for Weight Loss in Patients Without Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

  The American journal of cardiology · Moiz A, Levett JY, Filion KB, Peri K, et al.

• Randomized Controlled Trial · 2024

  Continued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity: The SURMOUNT-4 Randomized Clinical Trial

  JAMA · Aronne LJ, Sattar N, Horn DB, Bays HE, et al.

• Randomized Controlled Trial · 2022

  Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial

  JAMA · Rubino DM, Greenway FL, Khalid U, O'Neil PM, et al.

• Meta-Analysis · 2022

  Efficacy and Safety of Semaglutide for Weight Loss in Obesity Without Diabetes: A Systematic Review and Meta-Analysis

  Journal of the ASEAN Federation of Endocrine Societies · Tan HC, Dampil OA, Marquez MM

• Randomized Controlled Trial · 2021

  Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial

  JAMA · Rubino D, Abrahamsson N, Davies M, Hesse D, et al.

• Randomized Controlled Trial · 2021

  Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity: The STEP 3 Randomized Clinical Trial

  JAMA · Wadden TA, Bailey TS, Billings LK, Davies M, et al.

Where Weight Loss appears on Kindr Health