Estrogen

Authoritative sources

• Wikidata (Q132621)
• MeSH (D004967)
• Wikipedia

Evidence base

• Observational Cohort Study · 2023 · Landmark

  Menopausal Hormone Therapy and Risk of Dementia

  BMJ · Pourhadi N, Mørch LS, Holm EA, et al.

  A large Danish study suggested a small association between long-term HRT and dementia risk, but experts caution the study cannot prove HRT causes dementia and contradicts other evidence.

• Systematic Review · 2022 · Landmark

  Menopause and Adhesive Capsulitis of the Shoulder: A Systematic Review

  Journal of Shoulder and Elbow Surgery · Kingston K, Curry EJ, Galvin JW, Li X.

  A systematic review linking estrogen loss during menopause to a higher rate of frozen shoulder, and cautiously suggesting HRT may help.

• Randomized Controlled Trial · 2015 · Landmark

  Effects of Hormone Therapy on Cognition and Mood in Recently Postmenopausal Women

  PLoS Medicine · Gleason CE, Dowling NM, Wharton W, et al. (KEEPS Cognitive and Affective Study)

  When hormone therapy is started early in menopause, it does not appear to harm memory or thinking, and may improve mood.

• Randomized Controlled Trial · 2004 · Landmark

  Effects of Conjugated Equine Estrogen in Postmenopausal Women with Hysterectomy

  JAMA · Anderson GL, Limacher M, Assaf AR, et al.

  For women without a uterus, estrogen-only therapy showed a much more favorable risk profile than the combined therapy arm.

• Randomized Controlled Trial · 2002 · Landmark

  Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women

  JAMA · Rossouw JE, Anderson GL, Prentice RL, et al. (Writing Group for the Women's Health Initiative)

  The Women's Health Initiative was the landmark trial that reshaped how doctors prescribe hormone therapy after menopause. Later re-analyses showed the risk profile is very different for women who start HRT closer to menopause.

• Randomized Controlled Trial · 2025

  Imlunestrant with or without Abemaciclib in Advanced Breast Cancer

  The New England journal of medicine · Jhaveri KL, Neven P, Casalnuovo ML, Kim SB, et al.

• Randomized Controlled Trial · 2025

  First-Line Camizestrant for Emerging ESR1-Mutated Advanced Breast Cancer

  The New England journal of medicine · Bidard FC, Mayer EL, Park YH, Janni W, et al.

• Systematic Review · 2025

  The AUA/SUFU/AUGS Guideline on Genitourinary Syndrome of Menopause

  The Journal of urology · Kaufman MR, Ackerman AL, Amin KA, Coffey M, et al.

• Randomized Controlled Trial · 2025

  Vepdegestrant, a PROTAC Estrogen Receptor Degrader, in Advanced Breast Cancer

  The New England journal of medicine · Campone M, De Laurentiis M, Jhaveri K, Hu X, et al.

• Randomized Controlled Trial · 2024

  Elacestrant in ER+, HER2- Metastatic Breast Cancer with ESR1-Mutated Tumors: Subgroup Analyses from the Phase III EMERALD Trial by Prior Duration of Endocrine Therapy plus CDK4/6 Inhibitor and in Clinical Subgroups

  Clinical cancer research : an official journal of the American Association for Cancer Research · Bardia A, Cortés J, Bidard FC, Neven P, et al.

• Meta-Analysis · 2023

  Menstrual cycle hormones and oral contraceptives: a multimethod systems physiology-based review of their impact on key aspects of female physiology

  Journal of applied physiology (Bethesda, Md. : 1985) · D'Souza AC, Wageh M, Williams JS, Colenso-Semple LM, et al.

• Randomized Controlled Trial · 2022

  Elacestrant (oral selective estrogen receptor degrader) Versus Standard Endocrine Therapy for Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: Results From the Randomized Phase III EMERALD Trial

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology · Bidard FC, Kaklamani VG, Neven P, Streich G, et al.

• Meta-Analysis · 2022

  Soy Isoflavones and Breast Cancer Risk: A Meta-analysis

  In vivo (Athens, Greece) · Boutas I, Kontogeorgi A, Dimitrakakis C, Kalantaridou SN

• Meta-Analysis · 2021

  Neither soy nor isoflavone intake affects male reproductive hormones: An expanded and updated meta-analysis of clinical studies

  Reproductive toxicology (Elmsford, N.Y.) · Reed KE, Camargo J, Hamilton-Reeves J, Kurzer M, et al.

Where Estrogen appears on Kindr Health