Knowledge Graph · Symptom
Depression
A mood disorder causing persistent sadness and loss of interest.
Authoritative sources
Evidence base
Randomized Controlled Trial · 2015 · Landmark
Effects of Hormone Therapy on Cognition and Mood in Recently Postmenopausal Women
PLoS Medicine · Gleason CE, Dowling NM, Wharton W, et al. (KEEPS Cognitive and Affective Study)
When hormone therapy is started early in menopause, it does not appear to harm memory or thinking, and may improve mood.
Meta-Analysis · 2025
JAMA network open · Aaron RV, Ravyts SG, Carnahan ND, Bhattiprolu K, et al.
Meta-Analysis · 2024
Journal of affective disorders · Lu B, Lin L, Su X
Meta-Analysis · 2023
The serotonin theory of depression: a systematic umbrella review of the evidence
Molecular psychiatry · Moncrieff J, Cooper RE, Stockmann T, Amendola S, et al.
Randomized Controlled Trial · 2023
Zuranolone for the Treatment of Postpartum Depression
The American journal of psychiatry · Deligiannidis KM, Meltzer-Brody S, Maximos B, Peeper EQ, et al.
Meta-Analysis · 2022
Prevalence and Risk Factors of Postpartum Depression in Women: A Systematic Review and Meta-analysis
Journal of clinical nursing · Liu X, Wang S, Wang G
Meta-Analysis · 2021
The lancet. Gastroenterology & hepatology · Barberio B, Zamani M, Black CJ, Savarino EV, et al.
Systematic Review · 2021
JAMA psychiatry · Karyotaki E, Efthimiou O, Miguel C, Bermpohl FMG, et al.
Randomized Controlled Trial · 2021
Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial
JAMA psychiatry · Deligiannidis KM, Meltzer-Brody S, Gunduz-Bruce H, Doherty J, et al.
Where Depression appears on Kindr Health
Data hub
This page is part of Kindr Health's public Knowledge Graph. Content is for educational purposes only and is not medical advice.