Hormones · Menopause
DHEA in menopause: what it does and doesn't do
DHEA is a precursor hormone that declines with age. Intravaginal DHEA (prasterone, Intrarosa) is FDA-approved for genitourinary syndrome. Oral DHEA supplementation is more controversial — modest benefit for mood and libido in some women, no benefit in others.
Reasonable uses
- Vaginal prasterone 6.5mg for GSM
- Low-dose oral DHEA 10–25mg with documented low DHEA-S and symptoms
- Not for general anti-aging
Frequently asked questions
Should everyone take DHEA?
No. Targeted use for GSM (vaginal) or measured low DHEA-S with symptoms is reasonable.
Is DHEA safe?
Vaginal prasterone: yes. Oral DHEA at high doses: can cause acne, hair growth, mood shifts.
Does DHEA raise estrogen?
It converts to both estrogens and androgens peripherally; results vary by individual.
Considering a physician-supervised longevity protocol? Kindr Health evaluates peptide therapy as part of personalized perimenopause and menopause care.
Request your Longevity Consult →Explore Kindr Health
Related: FDA peptide review July 2026 briefing · Peptide therapy hub · Longevity service
Written and medically reviewed by the Kindr Health Clinical Team · Published 2026-06-19 · Last reviewed 2026-07-01. Compounded medications are prepared by FDA-registered 503A pharmacies and are not FDA-approved drug products.